Dudson, Michael Leigh (2020) Bioimpedance as a predictor of survival in renal failure and associated comorbidities. Masters thesis, Keele University.

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Abstract

Background: Renal failure requiring dialysis is associated with a high mortality. One of the contributing causes is overhydration. Overhydration can be assessed by bioimpedance analysis (BIA)– the non-invasive electrical measure of small current through the tissues that estimates the proportion of fluid that is intracellular water (ICW, typically muscle which is healthy) and extracellular (ECW, which in excess causes tissue oedema and is potentially dangerous). Several studies indicate that a extracellular water to total body water (TBW) ratio is associated with increased risk of death in dialysis patients but it is not clear if this is independent of other risk factors for death, namely comorbidity.

Aims and objectives: To establish the prognostic value of BIA in the prediction of survival on dialysis in the context of other known predictors of survival or hospitalisation. With further analysis of the applicability of the same scenario to heart failure patients.

Methodology: To conduct a systematic review using a standardised approach including a prespecified research question, search terms and criteria for study inclusion. With independent selection for inclusion in the study and quality appraisal by multiple authors with different backgrounds and experience.

Results: 2701 studies identified by literature search, plus an additional 4 through reference checking. 38 papers included in final analysis, 4 of which were regarding heart failure cohorts. Analysis of the research shows that BIA is an independent predictor of mortality.

Conclusion: BIA shown to be an independent predictor of mortality in dialysis patients, further research needed to extrapolate to heart failure (HF) populations.

Item Type: Thesis (Masters)
Additional Information: This electronic version of the thesis has been edited solely to ensure compliance with copyright legislation and excluded material is referenced in the text. The full, final, examined and awarded version of the thesis is available for consultation in hard copy via the University Library.
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Contributors: Davies, Simon (Thesis advisor)
Depositing User: Lisa Bailey
Date Deposited: 03 Jul 2020 11:54
Last Modified: 26 Aug 2020 12:00
URI: https://eprints.keele.ac.uk/id/eprint/8332

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