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Association of diabetes and hypertension with disease severity in covid-19 patients: A systematic literature review and exploratory meta-analysis

Parveen, Rizwana; Sehar, Nouroz; Bajpai, Ram; Agarwal, Nidhi Bharal

Association of diabetes and hypertension with disease severity in covid-19 patients: A systematic literature review and exploratory meta-analysis Thumbnail


Authors

Rizwana Parveen

Nouroz Sehar

Nidhi Bharal Agarwal



Abstract

Aim The novel coronavirus infection (COVID-19), now a worldwide public health concern is associated with varied fatality. Patients with chronic underlying conditions like diabetes and hypertension have shown worst outcomes. The understanding of the association might be helpful in early vigilant monitoring and better management of COVID-19 patients at high risk. The aim of the meta-analysis was to assess the association of diabetes and hypertension with severity of disease. Methods A literature search was conducted using the databases PubMed and Cochrane until March 31, 2020. Seven studies were included in the meta- analysis, including 2018 COVID-19 patients. Results Diabetes was lower in the survivors (OR: 0.56; 95%CI: 0.35–0.90; p = 0.017; I2: 0.0%) and non-severe (OR: 1.66; 95%CI: 1.20–2.30; p = 0.002; I2: 0.0%) patients. No association of diabetes was found with ICU care. Hypertension was positively associated with death (OR: 0.49; 95%CI: 0.34–0.73; p<0.001; I2: 0.0%), ICU care (OR: 0.42; 95%CI: 0.22–0.81; p = 0.009; I2: 0.0%) and severity (OR: 2.69; 95%CI: 1.27–5.73; p = 0.01; I2: 52.4%). Conclusions Our findings suggest that diabetes and hypertension have a negative effect on health status of COVID-19 patients. However, large prevalence studies demonstrating the consequences of comorbid diabetes and hypertension are urgently needed to understand the magnitude of these vexatious comorbidities.

Journal Article Type Article
Acceptance Date Jun 29, 2020
Online Publication Date Jul 3, 2020
Publication Date 2020-08
Publicly Available Date Mar 28, 2024
Journal Diabetes Research and Clinical Practice
Print ISSN 0168-8227
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 166
Article Number 108295
DOI https://doi.org/10.1016/j.diabres.2020.108295
Keywords COVID-19; Coronavirus; Diabetes; Hypertension; SARS-CoV-2
Publisher URL https://doi.org/10.1016/j.diabres.2020.108295