Partington, R ORCID: https://orcid.org/0000-0002-7362-0257, Muller, S ORCID: https://orcid.org/0000-0001-6645-5751, Mallen, CD ORCID: https://orcid.org/0000-0002-2677-1028, Abdul Sultan, A and Helliwell, T ORCID: https://orcid.org/0000-0003-3987-6045 (2020) Mortality among patients with polymyalgia rheumatica: A retrospective cohort study. Arthritis Care & Research.

[img]
Preview
Text
acr.24403.pdf - Accepted Version

Download (7MB) | Preview

Abstract

OBJECTIVE: To determine whether a diagnosis of polymyalgia rheumatica (PMR) is associated with premature mortality. METHODS: We extracted anonymised electronic medical records of patients over the age of 40 years, who were eligible for linkage with the Office for National Statistics (ONS) Death Registration dataset, from the Clinical Practice Research Datalink from 1990-2016. Patients with PMR were individually matched by age, sex and registered General Practice with up to 5 controls without PMR. The total number and proportion of deaths and mortality rates were calculated. The mortality rate ratio (MRR), with 95% confidence interval (CI), adjusted for age, sex, region, smoking status, body mass index (BMI), and alcohol consumption, was calculated using Poisson regression. The twenty most common causes of death were tabulated. RESULTS: 18,943 patients with PMR were matched to 87,801 controls. Mean (standard deviation) follow-up after date of diagnosis was 8.0 (4.4) years in patients with PMR, and 7.9 (4.6) in controls. PMR was not associated with an increase in the risk of death (adjusted MRR 1.00 [95% CI 0.97, 1.03]) compared to matched controls. Causes of death were broadly similar between patients with PMR and controls, although patients with PMR were slightly more likely to have a vascular cause of death recorded (24% vs 23%). CONCLUSIONS: A diagnosis with PMR does not appear to increase the risk of premature death. Minor variations in cause of death were observed, but overall this study is reassuring for patients with PMR and clinicians.

Item Type: Article
Additional Information: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/ACR.24403 The final version can be found with all relevant information at; https://onlinelibrary.wiley.com/doi/abs/10.1002/acr.24403
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC925 Diseases of the musculoskeletal system
Divisions: Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Related URLs:
Depositing User: Symplectic
Date Deposited: 14 Aug 2020 14:51
Last Modified: 14 Aug 2020 14:51
URI: https://eprints.keele.ac.uk/id/eprint/8552

Actions (login required)

View Item View Item