Solbak, MS, Henning, MK, England, A ORCID: https://orcid.org/0000-0001-6333-7776, Martinsen, AC, Aaløkken, TM and Johansen, S (2020) Impact of iodine concentration and scan parameters on image quality, contrast enhancement and radiation dose in thoracic CT. European Radiology Experimental, 4 (1).

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Abstract

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>We investigated the impact of varying contrast medium (CM) densities and x-ray tube potentials on contrast enhancement (CE), image quality and radiation dose in thoracic computed tomography (CT) using two different scanning techniques.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Seven plastic tubes containing seven different CM densities ranging from of 0 to 600 HU were positioned inside a commercial chest phantom with padding, representing three different patient sizes. Helical scans of the phantom in single-source mode were obtained with varying tube potentials from 70 to 140 kVp. A constant volume CT dose index (CTDIvol) depending on phantom size and automatic dose modulation was tested. CE (HU) and image quality (contrast-to-noise ratio, CNR) were measured for all combinations of CM density and tube potential. A reference threshold of CE and kVp was defined as ≥ 200 HU and 120 kVp.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>For the medium-sized phantom, with a specific CE of 100–600 HU, the diagnostic CE (200 HU) at 70 kVp was ~ 90% higher than at 120 kVp, for both scan techniques (<jats:italic>p</jats:italic> &lt; 0.001). Changes in CM density/specific HU together with lower kVp resulted in significantly higher CE and CNR (<jats:italic>p</jats:italic> &lt; 0.001). When changing only the kVp, no statistically significant differences were observed in CE or CNR (<jats:italic>p</jats:italic> ≥ 0.094), using both dose modulation and constant CTDIvol.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>For thoracic CT, diagnostic CE (≥ 200 HU) and maintained CNR were achieved by using lower CM density in combination with lower tube potential (&lt; 120 kVp), independently of phantom size.</jats:p> </jats:sec>

Item Type: Article
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Uncontrolled Keywords: Contrast media, Phantoms (imaging), Radiation dosage, Thorax, Tomography (x-ray computed)
Subjects: Q Science > Q Science (General)
Q Science > QM Human anatomy
T Technology > T Technology (General)
Divisions: Faculty of Medicine and Health Sciences > School of Allied Health Professions
Depositing User: Symplectic
Date Deposited: 17 Sep 2020 13:59
Last Modified: 17 Sep 2020 13:59
URI: https://eprints.keele.ac.uk/id/eprint/8663

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