Pana, T, Mohamed, M, Clark, A, Fahy, E, Mamas, M ORCID: https://orcid.org/0000-0001-9241-8890 and Myint, P (2020) Revascularisation Therapies Improve the Outcomes of Ischemic Stroke Patients with Atrial Fibrillation and Heart Failure. International Journal of Cardiology. (In Press)

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Abstract

Background – Atrial fibrillation (AF) and heart failure (HF) carry a poor prognosis in acute ischaemic stroke (AIS). The impact of revascularisation therapies on outcomes in these patients is not fully understood.

Methods –National Inpatient Sample (NIS) AIS admissions (January 2004-September 2015) were included (n=4,597,428). Logistic regressions analysed the relationship between exposures (neither AF nor HF-reference, AF-only, HF-only, AF+HF) and outcomes (in-hospital mortality, length-of-stay >median and moderate-to-severe disability on discharge), stratifying by receipt of intravenous thrombolysis (IVT) or endovascular thrombectomy (ET).

Results - 69.2% patients had neither AF nor HF, 16.5% had AF-only, 7.5% had HFonly and 6.7% had AF+HF. 5.04% and 0.72% patients underwent IVT and/or ET, respectively. AF-only and HF-only were each associated with 75-85% increase in the odds of in-hospital mortality. AF+HF was associated with greater than two-fold increase in mortality. Patients with AF-only, HF-only or AF+HF undergoing IVT had better or at least similar in-hospital outcomes compared to their counterparts not undergoing IVT, except for prolonged hospitalisation. Patients undergoing ET with AFonly, HF-only or AF+HF had better (in-hospital mortality, discharge disability, all-cause bleeding) or at least similar (length-of-stay) outcomes to their counterparts not undergoing ET. Compared to AIS patients without AF, AF patients had approximately 50% and more than two-fold increases in the likelihood of receiving IVT or ET, respectively.

Conclusions –We confirmed the combined and individual impact of co-existing AF or HF on important patient-related outcomes. Revascularisation therapies improve these outcomes significantly in patients with these comorbidities.

Item Type: Article
Uncontrolled Keywords: revascularisation, therapies, ischemic stroke, atrial fibrillation, heart failure
Subjects: R Medicine > RC Internal medicine > RC666 Diseases of the circulatory (Cardiovascular) system
Divisions: Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Depositing User: Symplectic
Date Deposited: 05 Oct 2020 10:30
Last Modified: 05 Oct 2020 11:27
URI: https://eprints.keele.ac.uk/id/eprint/8719

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