Ramsden, JI, Cosgrove, SC ORCID: https://orcid.org/0000-0001-9541-7201 and Turner, NJ (2020) Is it time for biocatalysis in fragment-based drug discovery? Chemical Science, 11 (41). 11104 - 11112.

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Abstract

The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature to demonstrate the potential for not only fragment generation, but also the enzyme-mediated elaboration of these fragments. Our analysis demonstrates that biocatalytic products can readily populate 3D chemical space, offering diverse catalytic approaches to help generate new, bioactive molecules.

Item Type: Article
Additional Information: The final version of this article and all relevant information related to it can be found online at; https://pubs.rsc.org/en/content/articlelanding/2020/SC/D0SC04103C#!divAbstract
Uncontrolled Keywords: fragment-based drug discovery, biocatalysis, chemistry
Subjects: R Medicine > R Medicine (General) > R735 Medical education. Medical schools. Research
R Medicine > RA Public aspects of medicine
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine
R Medicine > RZ Other systems of medicine
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 18 Nov 2020 12:38
Last Modified: 21 Nov 2020 15:25
URI: https://eprints.keele.ac.uk/id/eprint/8911

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