Keele Research Repository

Shoaib, A ORCID: https://orcid.org/0000-0003-0513-8319, Rashid, M ORCID: https://orcid.org/0000-0001-9725-1583, Kontopantelis, E, Sharp, A, Fahy, EF, Nolan, J, Townend, J, Ludman, P, Ratib, K, Azam, ZA, Ahmad, A, McEntegart, M, Mohamed, MO ORCID: https://orcid.org/0000-0002-9678-5222, Kinnaird, T, Mamas, MA ORCID: https://orcid.org/0000-0001-9241-8890, (BCIS), British Cardiovascular Intervention Society and (NICOR), National Institute for Cardiovascular Outcomes Research (2020) Clinical Characteristics and Outcomes From Percutaneous Coronary Intervention of Last Remaining Coronary Artery: An Analysis From the British Cardiovascular Intervention Society Database. Circulation: Cardiovascular Interventions, 13 (9). e009049 - ?.

Text LRPV Manuscript Ref .docx - Accepted Version Restricted to Repository staff only until 2 March 2021. Available under License Creative Commons Attribution Non-commercial. Download (15MB)

Abstract

BACKGROUND: Patients with complex high-risk coronary anatomy, such as those with a last remaining patent vessel (LRPV), are increasingly revascularized with percutaneous coronary intervention (PCI) in contemporary practice. There are limited data on the outcomes of these high-risk procedures. METHODS: We analyzed a large longitudinal PCI cohort (2007-2014, n=501 841) from the British Cardiovascular Intervention Society database. Clinical, demographic, procedural, and outcome data were analyzed by dividing patients into 2 groups; LRPV group (n=2432) and all other PCI groups (n=506 691). RESULTS: Patients in the LRPV PCI group were older, had more comorbidities, and higher prevalence of moderate-severe left ventricular systolic dysfunction. Mortality was higher in the LRPV PCI group during hospital admission (12 % versus 1.5 %, P<0.001), at 30 days (15% versus 2%, P<0.001), and at one-year (24% versus 5%, P<0.001). In a propensity score matching analysis the adjusted risk of mortality during index admission (odds ratio, 2.05 [95% CI, 1.65-2.44], P<0.001), at 30 days (odds ratio, 2.13 [95% CI, 1.78-2.5], P<0.001), at 1 year (odds ratio, 1.81 [95% CI, 1.59-2.03], P<0.001), and in-hospital major adverse cardiovascular events (odds ratio, 1.8 [95% CI, 1.42-2.19], P<0.001) were higher in LRPV PCI group as compared to control group. In sensitivity analyses, similar clinical outcomes were observed irrespective of which major epicardial coronary artery was treated. CONCLUSIONS: In this contemporary cohort, patients who had PCI to their LRPV had a higher-risk profile and more adverse clinical outcomes, irrespective of the vessel treated.

Item Type:	Article
Additional Information:	The final accepted version of this manuscript can be found online with all relevant copyrights information at; https://publications.keele.ac.uk/viewobject.html?id=167961&cid=1
Uncontrolled Keywords:	percutaneous coronary intervention; mortality; myocardial infarction; prevalence
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine > RC666 Diseases of the circulatory (Cardiovascular) system
Divisions:	Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Related URLs:	Author
Depositing User:	Symplectic
Date Deposited:	26 Nov 2020 11:49
Last Modified:	26 Nov 2020 11:49
URI:	https://eprints.keele.ac.uk/id/eprint/8935

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