Fang, L and Watkinson, M (2020) Subcellular localised small molecule fluorescent probes to image mobile Zn2+. Chemical Science, 11 (42). 11366 - 11379.

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Abstract

Zn2+, as the second most abundant d-block metal in the human body, plays an important role in a wide range of biological processes, and the dysfunction of its homeostasis is related to many diseases, including Type 2 diabetes, Alzheimer's disease and prostate and breast cancers. Small molecule fluorescent probes, as effective tools for real-time imaging, have been widely used to study Zn2+ related processes. However, the failure to control their localisation in cells has limited their utility somewhat, as they are generally incapable of studying individual processes in a specific cellular location. This perspective presents an overview of the recent developments in specific organelle localised small molecule fluorescent Zn2+ probes and their application in biological milieu, which could help to extend our understanding of the mechanisms that cells use to respond to dysfunction of zinc homeostasis and its roles in disease initiation and development.

Item Type: Article
Additional Information: This is the final published version (version of record). It was first published online via Royal Society of Chemistry at https://doi.org/10.1039/D0SC04568C - please refer to any applicable terms of use of the publisher.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 10 Dec 2020 14:03
Last Modified: 10 Dec 2020 14:03
URI: https://eprints.keele.ac.uk/id/eprint/9011

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