Matetic, A, Contractor, T, Mohamed, MO ORCID: https://orcid.org/0000-0002-9678-5222, Bhardwaj, R, Aneja, A, Myint, PK, Rakoski, MO, Zieroth, S, Paul, TK and Mamas, MA ORCID: https://orcid.org/0000-0001-9241-8890 (2020) Trends, management and outcomes of acute myocardial infarction in chronic liver disease. International Journal of Clinical Practice.

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Abstract

AIMS: There are limited data on the management and outcomes of chronic liver disease (CLD) patients presenting with acute myocardial infarction (AMI), particularly according to the subtype of CLD. METHODS: Using the Nationwide Inpatient Sample (2004-2015), we examined outcomes of AMI patients stratified by severity and sub-types of CLD. Multivariable logistic regression was performed to assess the adjusted odds ratios (aOR) of receipt of invasive management and adverse outcomes in CLD groups compared with no-CLD. RESULTS: Of 7 024 723 AMI admissions, 54 283 (0.8%) had a CLD diagnosis. CLD patients were less likely to undergo coronary angiography (CA) and percutaneous coronary intervention (PCI) (aOR 0.62, 95%CI 0.60-0.63 and 0.59, 95%CI 0.58-0.60, respectively), and had increased odds of adverse outcomes including major adverse cardiovascular and cerebrovascular events (1.19, 95%CI 1.15-1.23), mortality (1.30, 95%CI 1.25-1.34) and major bleeding (1.74, 95%CI 1.67-1.81). In comparison to the non-severe CLD sub-groups, patients with all forms of severe CLD had the lower utilization of CA and PCI (P < .05). Among severe CLD patients, those with alcohol-related liver disease (ALD) had the lowest utilization of CA and PCI; patients with ALD and other CLD (OCLD) had more adverse outcomes than the viral hepatitis sub-group (P < .05). CONCLUSIONS: CLD patients presenting with AMI are less likely to receive invasive management and are associated with worse clinical outcomes. Further differences are observed depending on the type as well as severity of CLD, with the worst management and clinical outcomes observed in those with severe ALD and OCLD.

Item Type: Article
Additional Information: The final accepted version of this manuscript and all relevant information related to it can be found online at; https://onlinelibrary.wiley.com/doi/10.1111/ijcp.13841
Uncontrolled Keywords: acute myocardial infarction; chronic liver disease; in‐hospital outcomes
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > R735 Medical education. Medical schools. Research
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine > RC845 Diseases of the liver, gallbladder, bile ducts, and pancreas
Divisions: Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Related URLs:
Depositing User: Symplectic
Date Deposited: 16 Dec 2020 15:33
Last Modified: 22 Dec 2020 09:27
URI: https://eprints.keele.ac.uk/id/eprint/9013

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