Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Perry, J, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Gallacher, P, Jermin, P and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2021) Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy. The Bone and Joint Journal, 103-B (S2).

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Abstract

Objectives
The ability to predict which patients will improve following routine surgeries aimed at preventing the progression of osteoarthritis is needed to aid patients being stratified to receive the most appropriate treatment. This study aimed to investigate the potential of a panel of biomarkers for predicting (prior to treatment) the clinical outcome following treatment with microfracture or osteotomy.

Methods
Proteins known to relate to OA severity, with predictive value in autologous cell implantation treatment or that had been identified in proteomic analyses (aggrecanase-1/ ADAMTS-4, cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), Lymphatic Vessel Endothelial Hyaluronan Receptor-1, matrix metalloproteinases-1 and −3, soluble CD14, S100 calcium binding protein A13 and 14-3-3 protein theta) were assessed in the synovial fluid (SF) of 19 and 13 patients prior to microfracture or osteotomy, respectively, using commercial immunoassays. Levels of COMP and HA were measured in the plasma of these patients. To find predictors of postoperative function, multiple linear regression analyses were performed.

Results
Linear regression analyses demonstrated that a lower concentration of HA in pre-operative SF was predictive of improved knee function (higher Lysholm score) following microfracture surgery. Further, lower pre-operative activity of ADAMTS-4 in SF was a significant, independent predictor of higher post-operative Lysholm score (improved joint function) following osteotomy surgery.

Conclusion
This study is novel in identifying biomarkers with the potential to predict clinical outcome in patients treated with microfracture or osteotomy of the knee. Lower concentrations of HA and undetectable activity of ADAMTS-4 in the joint fluid of individuals with cartilage defects/early-OA may be used in algorithms to stratify patients to the most appropriate surgery.

Item Type: Article
Additional Information: The published version of this accepted manuscript is available direct from the publishers. Please refer to any relevant terms and conditions.
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RD Surgery
R Medicine > RD Surgery > RD32 Operative surgery. Technique of surgical operations
Divisions: Faculty of Medicine and Health Sciences > School of Pharmacy and Bioengineering
Depositing User: Symplectic
Date Deposited: 23 Apr 2021 09:14
Last Modified: 13 May 2021 10:58
URI: https://eprints.keele.ac.uk/id/eprint/9358

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