Roddy, E ORCID: https://orcid.org/0000-0002-8954-7082 and Dalbeth, N (2021) Urate-lowering for blood pressure control in adults: another nail in the coffin? Arthritis and Rheumatology.

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Abstract

Numerous observational studies have reported an association between serum urate and elevated blood pressure in adult populations (1). These observations, together with experimental in vivo studies, have generated substantial interest in the role of hyperuricaemia as a mediator of elevated blood pressure, with various postulated mechanisms, including activation of renin-angiotensin system, oxidative stress, reduced endothelial nitric oxide availability, and renal vasoconstriction (2).

Item Type: Article
Additional Information: The published version of this accepted manuscript is available from the publisher at https://onlinelibrary.wiley.com/doi/10.1002/art.41751. Please refer to any relevant terms and conditions.
Uncontrolled Keywords: allopurinol; blood pressure; gout; urate
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Related URLs:
Depositing User: Symplectic
Date Deposited: 26 Apr 2021 11:52
Last Modified: 29 Apr 2021 14:07
URI: https://eprints.keele.ac.uk/id/eprint/9466

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