Monaco, G, El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678, Alini, M and Stoddart, MJ (2021) Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration. Journal of Functional Morphology and Kinesiology, 6 (1). pp. 1-32.

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Abstract

<jats:p>Articular cartilage injury and repair is an issue of growing importance. Although common, defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity, which is largely due to its avascular nature. There is a critical need to better study and understand cellular healing mechanisms to achieve more effective therapies for cartilage regeneration. This article aims to describe the key features of cartilage which is being modelled using tissue engineered cartilage constructs and ex vivo systems. These models have been used to investigate chondrogenic differentiation and to study the mechanisms of cartilage integration into the surrounding tissue. The review highlights the key regeneration principles of articular cartilage repair in healthy and diseased joints. Using co-culture models and novel bioreactor designs, the basis of regeneration is aligned with recent efforts for optimal therapeutic interventions.</jats:p>

Item Type: Article
Additional Information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Uncontrolled Keywords: bioreactors; osteochondral; integration; tissue engineering
Subjects: R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > R735 Medical education. Medical schools. Research
Divisions: Faculty of Medicine and Health Sciences > School of Pharmacy and Bioengineering
Depositing User: Symplectic
Date Deposited: 06 May 2021 07:31
Last Modified: 06 May 2021 07:31
URI: https://eprints.keele.ac.uk/id/eprint/9493

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