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Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration

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Abstract

<jats:p>Articular cartilage injury and repair is an issue of growing importance. Although common, defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity, which is largely due to its avascular nature. There is a critical need to better study and understand cellular healing mechanisms to achieve more effective therapies for cartilage regeneration. This article aims to describe the key features of cartilage which is being modelled using tissue engineered cartilage constructs and ex vivo systems. These models have been used to investigate chondrogenic differentiation and to study the mechanisms of cartilage integration into the surrounding tissue. The review highlights the key regeneration principles of articular cartilage repair in healthy and diseased joints. Using co-culture models and novel bioreactor designs, the basis of regeneration is aligned with recent efforts for optimal therapeutic interventions.</jats:p>

Acceptance Date Dec 23, 2020
Publication Date Jan 5, 2021
Publicly Available Date Mar 29, 2024
Journal Journal of Functional Morphology and Kinesiology
Print ISSN 2411-5142
Publisher MDPI
Pages 1-32
DOI https://doi.org/10.3390/jfmk6010006
Keywords bioreactors; osteochondral; integration; tissue engineering
Publisher URL https://www.mdpi.com/2411-5142/6/1/6

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