Mieke Guinan
Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues.
Guinan, Mieke; Benckendorff, Caecilie; Smith, Mark; Miller, Gavin
Authors
Abstract
Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds, including gemcitabine and cytarabine, are the go-to option in first-line treatments. However, these materials do have limitations and the development of next generation compounds remains a topic of significant interest and necessity. Herein, we discuss recent advances in the chemical synthesis and biological evaluation of nucleoside analogues as potential anticancer agents. Focus is paid to 4'-heteroatom substitution of the furanose oxygen, 2'-, 3'-, 4'- and 5'-position ring modifications and the development of new prodrug strategies for these materials.
Journal Article Type | Review |
---|---|
Acceptance Date | Apr 25, 2020 |
Publication Date | Apr 28, 2020 |
Publicly Available Date | Mar 29, 2024 |
Journal | Molecules |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 25 |
Issue | 9 |
DOI | https://doi.org/10.3390/molecules25092050 |
Keywords | nucleoside analogue; anti-cancer; chemical synthesis; heteroatom replacement; chemotherapeutic; prodrug |
Publisher URL | https://www.mdpi.com/1420-3049/25/9/2050 |
Files
molecules-25-02050-v2.pdf
(9.9 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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