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Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues.

Guinan, Mieke; Benckendorff, Caecilie; Smith, Mark; Miller, Gavin

Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. Thumbnail


Authors

Mieke Guinan

Mark Smith



Abstract

Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds, including gemcitabine and cytarabine, are the go-to option in first-line treatments. However, these materials do have limitations and the development of next generation compounds remains a topic of significant interest and necessity. Herein, we discuss recent advances in the chemical synthesis and biological evaluation of nucleoside analogues as potential anticancer agents. Focus is paid to 4'-heteroatom substitution of the furanose oxygen, 2'-, 3'-, 4'- and 5'-position ring modifications and the development of new prodrug strategies for these materials.

Journal Article Type Review
Acceptance Date Apr 25, 2020
Publication Date Apr 28, 2020
Publicly Available Date Mar 29, 2024
Journal Molecules
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 25
Issue 9
DOI https://doi.org/10.3390/molecules25092050
Keywords nucleoside analogue; anti-cancer; chemical synthesis; heteroatom replacement; chemotherapeutic; prodrug
Publisher URL https://www.mdpi.com/1420-3049/25/9/2050

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