Paul Horrocks p.d.horrocks@keele.ac.uk
Evaluation of bioluminescence-based assays of anti-malarial drug activity
Horrocks
Authors
Abstract
Transgenic Plasmodium falciparum expressing luciferase offers an attractive bioluminescence-based assay platform for the investigation of the pharmacological properties of anti-malarial drugs. Here a side-by-side comparison of bioluminescence and fluorescence-based assays, utilizing a luciferase reporter cassette that confers a strong temporal pattern of luciferase expression during the S-phase of intraerythrocytic development, is reported.
Acceptance Date | Feb 3, 2013 |
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Publication Date | Feb 8, 2013 |
Publicly Available Date | Mar 28, 2024 |
Journal | Malaria Journal |
Publisher | Springer Verlag |
Pages | 58 - ? |
DOI | https://doi.org/10.1186/1475-2875-12-58 |
Keywords | luciferase, sybr green I, antimalarial drug, relative rate of kill, malaria |
Publisher URL | http://www.malariajournal.com/content/12/1/58 |
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