An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31

Chakravorty, Srabasti J.; McGettrick, Helen M.; Butler, Lynn M.; Buckley, Christopher D.; Rainger, G.  Ed; Nash, Gerard B.

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Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion (2002)
Journal Article

Fractalkine (CX3CL1) is a transmembrane molecule with a CX3C chemokine domain attached to an extracellular mucin stalk which can induce both adhesion and migration of leucocytes. Mononuclear cell infiltration at renal tubular sites and associated tub... Read More about Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion.

The role of ICAM-1 in Plasmodium falciparum cytoadherence (2004)
Journal Article

Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1)... Read More about The role of ICAM-1 in Plasmodium falciparum cytoadherence.

PfEMP1 expression is reduced on the surface of knoblessPlasmodium falciparuminfected erythrocytes (2005)
Journal Article

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a key virulence factor for this species of human malarial parasite. PfEMP1 is expressed on the surface of infected erythrocytes (IEs) and directly mediates adhesion to a variety of... Read More about PfEMP1 expression is reduced on the surface of knoblessPlasmodium falciparuminfected erythrocytes.

Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1 (2006)
Journal Article

Adhesion of Plasmodium falciparum-infected erythrocytes (IE) to host endothelium has been associated with pathology in malaria. Although the interaction with endothelial cells can be complex due to the relatively large number of host receptors availa... Read More about Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1.

An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31 (2006)
Journal Article

To model the later stages of neutrophil migration into tissue, we developed an assay in which human umbilical vein endothelial cells (HUVEC) were cultured on porous filters, treated with the inflammatory cytokine tumour necrosis factor-α (TNF), and t... Read More about An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31.