Pongener, I, O'Shea, C, Wootton, H, Watkinson, M and Miller, GJ (2021) Developments in the Chemical Synthesis of Heparin and Heparan Sulfate. The Chemical Record, 21 (11). pp. 3238-3255. ISSN 1527-8999

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Heparin and heparan sulfate represent key members of the glycosaminoglycan family of carbohydrates and underpin considerable repertoires of biological importance. As such, their efficiency of synthesis represents a key requirement, to further understand and exploit the H/HS structure-to-biological function axis. In this review we focus on chemical approaches to and methodology improvements for the synthesis of these essential sugars (from 2015 onwards). We first consider advances in accessing the heparin-derived pentasaccharide anticoagulant fondaparinux. This is followed by heparan sulfate targets, including key building block synthesis, oligosaccharide construction and chemical sulfation techniques. We end with a consideration of technological improvements to traditional, solution-phase synthesis approaches that are increasingly being utilised.

Item Type: Article
Additional Information: © 2021 The Authors. Published by The Chemical Society of Japan & Wiley-VCH GmbH The final version of this article and all information relevant to it, including copyrights, can be found online at; https://onlinelibrary.wiley.com/doi/10.1002/tcr.202100173
Uncontrolled Keywords: carbohydrates; heparan sulfate; heparin; glycosaminoglycan; glycosylation
Subjects: Q Science > QD Chemistry
Q Science > QD Chemistry > QD415 Biochemistry
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 23 Sep 2021 07:56
Last Modified: 29 Nov 2021 11:01
URI: https://eprints.keele.ac.uk/id/eprint/10053

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