Keele Research Repository

<jats:title>Abstract</jats:title> <jats:sec id="S0022215121002462_sec_a1"> <jats:title>Objective</jats:title> <jats:p>Patients with coronavirus disease vaccine associated lymphadenopathy are increasingly being referred to healthcare services. This work is the first to report on the incidence, clinical course and imaging features of coronavirus disease vaccine associated cervical lymphadenopathy, with special emphasis on the implications for head and neck cancer services.</jats:p> </jats:sec> <jats:sec id="S0022215121002462_sec_a2" sec-type="methods"> <jats:title>Methods</jats:title> <jats:p>This was a retrospective cohort study of all patients referred to our head and neck cancer clinics between 16 December 2020 and 12 March 2021. The main outcomes measured were the proportion of patients with vaccine-associated cervical lymphadenopathy, and the clinical and imaging characteristics.</jats:p> </jats:sec> <jats:sec id="S0022215121002462_sec_a3" sec-type="results"> <jats:title>Results</jats:title> <jats:p>The incidence of vaccine-associated cervical lymphadenopathy referrals was 14.8 per cent (<jats:italic>n</jats:italic> = 13). Five patients (38.5 per cent) had abnormal-looking enlarged and rounded nodes with increased vascularity. Only seven patients (53.9 per cent) reported full resolution within an average of 3.1 ± 2.3 weeks.</jats:p> </jats:sec> <jats:sec id="S0022215121002462_sec_a4" sec-type="conclusions"> <jats:title>Conclusion</jats:title> <jats:p>Coronavirus disease vaccine associated cervical lymphadenopathy can mimic malignant lymphadenopathy and therefore might prove challenging to diagnose and manage correctly. Healthcare services may encounter a significant increase in referrals.</jats:p> </jats:sec>