Stanislaw Glazewski
Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates.
Glazewski, Stanislaw; Barth, Alison L.
Authors
Alison L. Barth
Abstract
Although subthreshold inputs of neocortical sensory neurons are broadly tuned, the spiking output is more restricted. These subthreshold inputs provide a substrate for stimulus intensity-dependent changes their spiking output, as well as for experience-dependent plasticity to alter firing properties. Here we investigated how different stimulus intensities modified the firing output of individual neurons in layer 2/3 of the mouse barrel cortex. Decreasing stimulus intensity over a 30-fold range lowered the firing rates evoked by principal whisker stimulation and reduced the overall size of the responding ensemble in whisker-undeprived animals. We then examined how these responses were changed after single-whisker experience (SWE). After 7 days of SWE, the mean magnitude of response to spared whisker stimulation at the highest stimulus intensity was not altered. However, lower-intensity whisker stimulation revealed a more than 10-fold increase in mean firing output compared with control animals. Also, under control conditions, only ~15% of neurons showed any firing at low stimulus intensity, compared with more than 70% of neurons after SWE. However, response changes measured in the immediately surrounding representations were detected only for the highest stimulus intensity. Overall, these data showed that the measurement of experience-dependent changes in the spike output of neocortical neurons was highly dependent upon stimulus intensity.
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 18, 2014 |
Publication Date | Feb 1, 2015 |
Publicly Available Date | Mar 28, 2024 |
Journal | Eur J Neurosci |
Print ISSN | 0953-816X |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 41 |
Issue | 4 |
Pages | 410 - 419 |
DOI | https://doi.org/10.1111/ejn.12805 |
Keywords | cortical circuitry;glutamatergic neurotransmission;learning and memory;mouse;neocortex;plasticity |
Publisher URL | http://onlinelibrary.wiley.com/doi/10.1111/ejn.12805/suppinfo |
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