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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

Alexander, Stephen P. H.; Fabbro, Doriano; Kelly, Eamonn; Mathie, Alistair; Peters, John A.; Veale, Emma L.; Armstrong, Jane F.; Faccenda, Elena; Harding, Simon D.; Pawson, Adam J.; Southan, Christopher; Davies, Jamie A.; Boison, Detlev; Burns, Kathryn Elisa; Dessauer, Carmen; Gertsch, Jurg; Helsby, Nuala Ann; Izzo, Angelo A.; Koesling, Doris; Ostrom, Rennolds; Pyne, Nigel J.; Pyne, Susan; Russwurm, Michael; Seifert, Roland; Stasch, Johannes-Peter; van der Stelt, Mario; van der Vliet, Albert; Watts, Val; Wong, Szu Shen

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Authors

Stephen P. H. Alexander

Doriano Fabbro

Eamonn Kelly

Alistair Mathie

John A. Peters

Emma L. Veale

Jane F. Armstrong

Elena Faccenda

Simon D. Harding

Adam J. Pawson

Christopher Southan

Jamie A. Davies

Detlev Boison

Kathryn Elisa Burns

Carmen Dessauer

Jurg Gertsch

Nuala Ann Helsby

Angelo A. Izzo

Doris Koesling

Rennolds Ostrom

Nigel J. Pyne

Susan Pyne

Michael Russwurm

Roland Seifert

Johannes-Peter Stasch

Mario van der Stelt

Albert van der Vliet

Val Watts



Abstract

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15542. Enzymes are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

Journal Article Type Article
Acceptance Date Sep 16, 2021
Online Publication Date Sep 16, 2021
Publication Date 2021-10
Publicly Available Date May 30, 2023
Journal British Journal of Pharmacology
Print ISSN 0007-1188
Publisher Wiley
Volume 178
Issue S1
Pages S313 - S411
DOI https://doi.org/10.1111/bph.15542
Publisher URL https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15542

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