Wu, P, Sharma, G, Mehta, L, Chew-Graham, CA, Lundberg, G, Nerenberg, K, Graham, M, Chappell, L, Kadam, UT, Jordan, KP and Mamas, MA (2022) In-hospital complications in pregnancies conceived by assisted reproductive technology. Journal of the American Heart Association, 11 (5). ISSN 2047-9980

[thumbnail of Supplemental materials JAHA R1 clean.docx] Text
Supplemental materials JAHA R1 clean.docx - Supplemental Material

Download (112kB)
[thumbnail of IVF manuscript JAHA R1 clean.docx] Text
IVF manuscript JAHA R1 clean.docx - Accepted Version

Download (379kB)
[thumbnail of JAHA.121.022658.pdf]
JAHA.121.022658.pdf - Published Version

Download (793kB) | Preview


Assisted reproductive technology (ART) has emerged as a common treatment option for infertility, a problem that affects an estimated 48 million couples worldwide. Advancing maternal age with increasing pre-pregnancy cardiovascular risk factors, such as chronic hypertension, obesity and diabetes, has raised concerns about pregnancy complications associated with ART. However, in-hospital complications following pregnancies conceived by ART are poorly described.

Methods and Results
To assess the patient characteristics, obstetric outcomes, vascular complications and temporal trends of pregnancies conceived by ART, we analysed hospital deliveries conceived with or without ART between January 1, 2008 and December 31, 2016 from the United States National Inpatient Sample database. We included 106,248 deliveries conceived with ART and 34,167,246 deliveries conceived without ART. Women who conceived with ART were older (35 vs. 28 years, p<0.0001) and had more comorbidities. ART-conceived pregnancies were independently associated with vascular complications (acute kidney injury aOR 2.52, 95% CI 1.99, 3.19, arrhythmia aOR 1.65, 95% CI 1.46, 1.86), and adverse obstetric outcomes (placental abruption aOR 1.57, 95% CI 1.41, 1.74, Cesarean delivery aOR 1.38, 95% CI 1.33, 1.43 and preterm birth aOR 1.26, 95% CI 1.20, 1.32), including in subgroups without CVD risk factors or without multifetal pregnancies. Higher hospital charges ($18,705 vs. $11,983, p<0.0001) were incurred compared to women who conceived without ART.

Pregnancies conceived by ART have higher risks of adverse obstetric outcomes and vascular complications compared with spontaneous conception. Clinicians should have detailed discussions on the associated complications of ART in women during pre-pregnancy counselling.

Item Type: Article
Additional Information: Copyright © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Uncontrolled Keywords: cardiovascular disease risk factors; in vitro fertilization; pregnancy; prevention
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RG Gynecology and obstetrics
R Medicine > RJ Pediatrics
Divisions: Faculty of Medicine and Health Sciences > School of Medicine
Depositing User: Symplectic
Date Deposited: 21 Dec 2021 14:15
Last Modified: 22 Apr 2022 14:10
URI: https://eprints.keele.ac.uk/id/eprint/10422

Actions (login required)

View Item
View Item