Reaching new biocatalytic reactivity using continuous flow reactors

Cosgrove, Sebastian C.

doi:10.1002/chem.202103607

Reaching new biocatalytic reactivity using continuous flow reactors

Cosgrove, Sebastian C.

Authors

Sebastian Cosgrove s.cosgrove@keele.ac.uk

Abstract

The use of flow reactors in biocatalysis has increased significantly in recent years. Chemists have begun to design flow systems that even allow new biocatalytic reactions to take place. This concept article will focus on the design of flow systems that have allowed enzymes to go beyond their limits in batch. The case is made for moving towards fully continuous systems. With flow chemistry increasingly seen as an enabling technology for automated synthesis, and with advancements in AI assisted enzyme design, there is a real possibility to fully automate the development and implementation of a continuous biocatalytic processes. This will lead to significantly improved enzyme processes for synthesis.

Journal Article Type	Review
Acceptance Date	Dec 9, 2021
Online Publication Date	Dec 9, 2021
Publication Date	Mar 1, 2022
Journal	Chemistry – A European Journal
Print ISSN	0947-6539
Publisher	Wiley
Peer Reviewed	Peer Reviewed
Volume	28
Issue	13
DOI	https://doi.org/10.1002/chem.202103607
Keywords	Biocatalysis; Biocatalytic Cascades; Continuous Flow Biocatalysis; Immobilisation
Publisher URL	https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202103607