Oxidase enzymes as sustainable oxidation catalysts

Wahart, Alice J. C.; Staniland, Jessica; Miller, Gavin J.; Cosgrove, Sebastian C.

doi:10.1098/rsos.211572

Oxidase enzymes as sustainable oxidation catalysts

Wahart, Alice J. C.; Staniland, Jessica; Miller, Gavin J.; Cosgrove, Sebastian C.

Authors

Alice J. C. Wahart

Jessica Staniland

Gavin Miller g.j.miller@keele.ac.uk

Sebastian Cosgrove s.cosgrove@keele.ac.uk

Abstract

Oxidation is one of the most important processes used by the chemical industry. However, many of the methods that are used pose significant sustainability and environmental issues. Biocatalytic oxidation offers an alternative to these methods, with a now significant enzymatic oxidation toolbox on offer to chemists. Oxidases are one of these options, and as they only depend on molecular oxygen as a terminal oxidant offer perfect atom economy alongside the selectivity benefits afforded by enzymes. This review will focus on examples of oxidase biocatalysts that have been used for the sustainable production of important molecules and highlight some important processes that have been significantly improved through the use of oxidases. It will also consider emerging classes of oxidases, and how they might fit in a future biorefinery approach for the sustainable production of important chemicals.

Journal Article Type	Review
Acceptance Date	Dec 3, 2021
Online Publication Date	Jan 12, 2022
Publication Date	2022-01
Journal	Royal Society Open Science
Publisher	The Royal Society
Peer Reviewed	Peer Reviewed
Volume	9
Issue	1
DOI	https://doi.org/10.1098/rsos.211572
Keywords	oxidases; biocatalysis; sustainable oxidation; alcohol oxidation; amine oxidation
Publisher URL	https://royalsocietypublishing.org/doi/10.1098/rsos.211572