Di Rosa, E, Mapelli, D, Ronconi, L, Macchia, E, Gentili, C, Bisiacchi, P and Edelstyn, NMJ (2022) Anxiety predicts impulsive-compulsive behaviours in Parkinson’s Disease: clinical relevance and theoretical implications. Journal of Psychiatry Research, 148. pp. 220-229. ISSN 0022-3956

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Patients with Parkinson’s Disease (PD) often present symptoms of anxiety, depression and apathy. These negative affect manifestations have been recently associated with the presence of Impulsive-Compulsive Behaviours (ICBs). However, their relation with the use of dopamine replacement therapy (DRT), a renewed risk factor for ICBs, is still not fully understood. Elucidating the role of these different ICBs predictors in PD could inform both prevention/intervention recommendations as well as theoretical models. In the present study we have analyzed data collected in 417 PD patients, 50 patients with parkinsonian symptoms but with scan without evidence of dopaminergic deficit (SWEDD), and 185 healthy controls (HC). We examined their clinical profile over a two-year’s time window, investigating the role of both negative affect and DRT on ICBs. Results confirmed the presence of higher levels of anxiety in both the clinical groups, and of higher level of ICBs in SWEDD patients, respect to both PD and HC. Mixed model analysis’ results also revealed a significant association between anxiety and ICBs in the SWEDD patients, who did not take any DRT. Findings suggest the independence between the role of anxiety and DRT in ICBs development and provide new evidence for the motivational opponency theoretical framework.

Item Type: Article
Additional Information: The final version of this article and all relevant information related to it, including copyrights, can be found on the publisher website.
Uncontrolled Keywords: Impulsivity; Negative affect; Anxiety; Depression; Parkinson's disease; SWEDD
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC346 Neurology. Diseases of the nervous system, including speech disorders
Divisions: Faculty of Natural Sciences > School of Psychology
Depositing User: Symplectic
Date Deposited: 27 Jan 2022 16:28
Last Modified: 29 Jan 2023 01:30
URI: https://eprints.keele.ac.uk/id/eprint/10548

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