Keele Research Repository
Explore the Repository
Quicke, JG, Conaghan, PG, Corp, N and Peat, G (2022) Osteoarthritis year in review 2021: epidemiology & therapy. Osteoarthritis and Cartilage, 30 (2). 196 - 206. ISSN 1522-9653
PIIS1063458421009341.pdf - Published Version
Download (1MB) | Preview
Abstract
This "Year in review" presents a selection of research themes and individual studies from the clinical osteoarthritis (OA) field (epidemiology and therapy) and includes noteworthy descriptive, analytical-observational, and intervention studies. The electronic database search for the review was conducted in Medline, Embase and medRxiv (15th April 2020 to 1st April 2021). Following study screening, the following OA-related themes emerged: COVID-19; disease burden; occupational risk; prediction models; cartilage loss and pain; stem cell treatments; novel pharmacotherapy trials; therapy for less well researched OA phenotypes; benefits and challenges of Individual Participant Data (IPD) meta-analyses; patient choice-balancing benefits and harms; OA and comorbidity; and inequalities in OA. Headline study findings included: a longitudinal cohort study demonstrating no evidence for a harmful effect of non-steroidal anti-inflammatory drugs (NSAIDs) in terms of COVID-19 related deaths; a Global Burden of Disease study reporting a 102% increase in crude incidence rate of OA in 2017 compared to 1990; a longitudinal study reporting cartilage thickness loss was associated with only a very small degree of worsening in pain over 2 years; an exploratory analysis of a non-OA randomised controlled trial (RCT) finding reduced risk of total joint replacement with an Interleukin -1β inhibitor (canakinumab); a significant relationship between cumulative disadvantage and clinical outcomes of pain and depression mediated by perceived discrimination in a secondary analysis from a RCT; worsening socioeconomic circumstances were associated with future arthritis diagnosis in an innovative natural experiment (with implications for unique research possibilities arising from the COVID-19 pandemic context).
Item Type: | Article |
---|---|
Additional Information: | 1063-4584/© 2021 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Osteoarthritis and Cartilage 30 (2022) 196e206 |
Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine > RC925 Diseases of the musculoskeletal system |
Divisions: | Faculty of Medicine and Health Sciences > School of Medicine |
Related URLs: | |
Depositing User: | Symplectic |
Date Deposited: | 16 Feb 2022 11:57 |
Last Modified: | 16 Feb 2022 11:57 |
URI: | https://eprints.keele.ac.uk/id/eprint/10616 |