Mohamed, MO, Van Spall, HG, Morillo, CA, Wilton, S and Mamas, MA (2022) THE IMPACT OF COMORBIDITY BURDEN ON DE NOVO CIED PROCEDURAL OUTCOMES: INSIGHTS FROM THE NATIONAL INPATIENT SAMPLE. Journal of the American College of Cardiology, 79 (9). 185 - 185. ISSN 0735-1097

[thumbnail of 1-s2.0-S0735109722011767-main.pdf] Text
1-s2.0-S0735109722011767-main.pdf - Published Version
Restricted to Repository staff only

Download (152kB)


Limited data exist on the impact of comorbidity burden on procedural outcomes after de novo cardiac implantable electronic device (CIED) implantation.

De novo CIED implantations in the National Inpatient Sample between 2015 and 2018 were analysed, stratified by Charlson comorbidity index (CCI) score into four comorbidity burden severity categories; CCI-0: none, CCI-1: mild, CCI-2: moderate, CCI-3+: severe. Multivariable logistic regression models were employed to study the association between unit CCI score and in-hospital adverse outcomes.

A total of 474,475 de novo CIED implantation procedures, the distribution of CCI score was as follows: CCI-0 (17.7%), CCI-1 (21.8%), CCI-2 (18.7%), CCI-3+ (41.8%). There was a positive correlation between CCI score and increased odds ratios (OR) of MACCE (1.10; 95% CI 1.09, 1.11), all-cause mortality (1.23; 95% CI 1.21, 1.25) and acute stroke (1.45; 95% CI 1.44, 1.46). (see Figure 1) A higher CCI score was not associated with increased odds of procedural (thoracic and cardiac) and device-related complications.

In this national analysis we demonstrate an increased risk of in-hospital mortality and acute ischemic stroke, but not procedure-related (thoracic, cardiac or device-related) complications, with higher comorbidity burden as measured by CCI score. An objective assessment of comorbidity burden using established scores is warranted when risk-stratifying patients undergoing CIED implantation.

Item Type: Article
Additional Information: The final version of this article and all relevant information related to it, including copyrights, can be found on the publisher website.
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > School of Medicine
Related URLs:
Depositing User: Symplectic
Date Deposited: 26 May 2022 08:09
Last Modified: 26 May 2022 08:09

Actions (login required)

View Item
View Item