Richardson, Monica Eilertsen (2012) Heterocyclic NO-donors as anti-cancer agents. Doctoral thesis, Keele University.

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Abstract

Nitric oxide (NO) is involved in numerous biological processes including cancer, where this small diatomic radical can exert both pro- and anti-cancer effects. Two series of novel NO-donors were synthesised in this work, the first representing an extension to the S-nitrosothiols (RSNO) class, with the second utilising the popular 1,2,5-oxadiazole-2-oxide (furoxan) functionality. The oxathiazolylium-5-olates 39a, 39f, 39h-D, were successfully made via improved seven-step synthesis whilst a series of combretastatin-like furoxans 144a-c (NO-hybrids) were generated in a one-pot reaction. All compounds; including byproducts from failed alternative synthetic routes, had their cytotoxic activity evaluated. From this study NO-hybrid 144c showed the most promising biological profile when tested against eight different ovarian cancer cell lines.

Item Type: Thesis (Doctoral)
Subjects: Q Science > QD Chemistry > QD415 Biochemistry
Divisions: Faculty of Natural Sciences > School of Physical and Geographical Sciences
Depositing User: Lisa Bailey
Date Deposited: 15 Aug 2022 11:15
Last Modified: 15 Aug 2022 11:15
URI: https://eprints.keele.ac.uk/id/eprint/11275

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