Mamas Mamas m.mamas@keele.ac.uk
Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Mamas
Authors
Abstract
Various studies have suggested the possible cardiovascular (CV) protective effects of the pneumococcal vaccine (PV). Therefore, we conducted a meta-analysis to assess the association between recipients of PV with mortality and CV outcomes among patients with and without established cardiovascular disease. We performed a systematic literature search in PubMed, Embase, and Scopus for studies evaluating the effect of PV on mortality and CV outcomes. A total of 15 studies with 347,444 patients were included in the meta-analysis: 111,784 patients received PV (32%) and 235,660 patients were in the unvaccinated group (68%). Recipients of PV were associated with decreased all-cause mortality (HR, 0.76 (95% CI: 0.66 to 0.87), p < 0.001). PV was associated with a decrease in the incidence of myocardial infarction (MI) (HR, 0.73 (95% CI: 0.56-0.96), p = 0.02), without significant reduction in CV mortality (HR, 0.87 (95% CI: 0.72-1.07), p = 0.18) and stroke (HR, 1.01 (95% CI: 0.93-1.10), p = 0.82). Our study found PV was associated with decreased risk of all-cause mortality and MI. Future RCTs will be necessary to confirm benefits associated with receipt of PV.
Acceptance Date | Jun 27, 2022 |
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Publication Date | Jun 30, 2022 |
Journal | Journal of Clinical Medicine |
Print ISSN | 2077-0383 |
Publisher | MDPI |
Pages | 3799 - 3799 |
DOI | https://doi.org/10.3390/jcm11133799 |
Keywords | pneumococcal vaccine; 23 PV vaccine; myocardial infarction; stroke; mortality |
Publisher URL | https://www.mdpi.com/2077-0383/11/13/3799 |
Additional Information | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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