Jaiswal, V, Ang, SP, Lnu, K, Ishak, A, Pokhrel, NB, Chia, JE, Hajra, A, Biswas, M, Matetic, A, Dhatt, R and Mamas, MA (2022) Effect of Pneumococcal Vaccine on Mortality and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 11 (13). 3799 - 3799. ISSN 2077-0383

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Various studies have suggested the possible cardiovascular (CV) protective effects of the pneumococcal vaccine (PV). Therefore, we conducted a meta-analysis to assess the association between recipients of PV with mortality and CV outcomes among patients with and without established cardiovascular disease. We performed a systematic literature search in PubMed, Embase, and Scopus for studies evaluating the effect of PV on mortality and CV outcomes. A total of 15 studies with 347,444 patients were included in the meta-analysis: 111,784 patients received PV (32%) and 235,660 patients were in the unvaccinated group (68%). Recipients of PV were associated with decreased all-cause mortality (HR, 0.76 (95% CI: 0.66 to 0.87), p < 0.001). PV was associated with a decrease in the incidence of myocardial infarction (MI) (HR, 0.73 (95% CI: 0.56-0.96), p = 0.02), without significant reduction in CV mortality (HR, 0.87 (95% CI: 0.72-1.07), p = 0.18) and stroke (HR, 1.01 (95% CI: 0.93-1.10), p = 0.82). Our study found PV was associated with decreased risk of all-cause mortality and MI. Future RCTs will be necessary to confirm benefits associated with receipt of PV.

Item Type: Article
Additional Information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: pneumococcal vaccine; 23 PV vaccine; myocardial infarction; stroke; mortality
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine > RC666 Diseases of the circulatory (Cardiovascular) system
Divisions: Faculty of Medicine and Health Sciences > School of Medicine
Depositing User: Symplectic
Date Deposited: 01 Sep 2022 09:22
Last Modified: 14 Oct 2022 08:36
URI: https://eprints.keele.ac.uk/id/eprint/11353

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