A Reversibly Porous Supramolecular Peptide Framework**

Brightwell, Dominic F.; Truccolo, Giada; Samanta, Kushal; Fenn, Elliott J.; Holder, Simon J.; Shepherd, Helena J.; Hawes, Chris S.; Palma, Aniello

doi:10.1002/chem.202202368

A Reversibly Porous Supramolecular Peptide Framework**

Brightwell, Dominic F.; Truccolo, Giada; Samanta, Kushal; Fenn, Elliott J.; Holder, Simon J.; Shepherd, Helena J.; Hawes, Chris S.; Palma, Aniello

Authors

Dominic F. Brightwell

Giada Truccolo

Kushal Samanta

Elliott J. Fenn

Simon J. Holder

Helena J. Shepherd

Chris Hawes c.s.hawes@keele.ac.uk

Aniello Palma

Abstract

The ability to use bio‐inspired building blocks in the assembly of novel supramolecular frameworks is at the forefront of an exciting research field. Herein, we present the first polyproline helix to self‐assemble into a reversibly porous, crystalline, supramolecular peptide framework (SPF). This framework is assembled from a short oligoproline, adopting the polyproline II conformation, driven by hydrogen‐bonding and dispersion interactions. Thermal activation, guest‐induced dynamic porosity and enantioselective guest inclusion have been demonstrated for this novel system. The principles of the self‐assembly associated with this SPF will be used as a blueprint allowing for the further development of helical peptide linkers in the rational design of SPFs and metal‐peptide frameworks.

Journal Article Type	Article
Acceptance Date	Aug 30, 2022
Online Publication Date	Sep 1, 2023
Publication Date	Aug 30, 2022
Publicly Available Date	May 30, 2023
Journal	Chemistry – A European Journal
Print ISSN	0947-6539
Publisher	Wiley
Volume	28
Issue	66
DOI	https://doi.org/10.1002/chem.202202368
Keywords	General Chemistry, Catalysis, Organic Chemistry
Publisher URL	https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202202368