Brightwell, DF, Truccolo, G, Samanta, K, Fenn, EJ, Holder, SJ, Shepherd, HJ, Hawes, CS and Palma, A (2022) A Reversibly Porous Supramolecular Peptide Framework. Chemistry: A European Journal. ISSN 0947-6539

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Chemistry A European J - 2022 - Brightwell - A Reversibly Porous Supramolecular Peptide Framework.pdf - Accepted Version

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The ability to use bio-inspired building-blocks in the assembly of novel supramolecular frameworks is at the forefront of this exciting research field. Herein, we present the first polyproline helix to self-assemble into a reversibly porous, crystalline, supramolecular peptide framework (SPF). This framework is assembled from a short oligoproline, adopting the polyproline II conformation, driven by hydrogen-bonding and dispersion interactions. Thermal activation, guest-induced dynamic porosity and enantioselective guest inclusion have been demonstrated for this novel system. The principles of the self-assembly associated with this SPF will be used as a blueprint allowing for the further development of helical peptide linkers in the rational design of SPFs and metalpeptide frameworks.

Item Type: Article
Additional Information: This manuscript has been accepted after peer review and appears as an Accepted Article online prior to editing, proofing, and formal publication of the final Version of Record (VoR). The VoR will be published online in Early View as soon as possible and may be different to this Accepted Article as a result of editing. Readers should obtain the VoR from the journal website shown below when it is published to ensure accuracy of information. The authors are responsible for the content of this Accepted Article. All relevant information related to this article, including copyrights, can be found on the publisher website.
Uncontrolled Keywords: enantioselectivity 1; helical structures2; host-guest systems 3; peptides4; supramolecular chemistry 5
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
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Depositing User: Symplectic
Date Deposited: 14 Sep 2022 10:00
Last Modified: 14 Sep 2022 10:00

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