Dengue outbreaks in Bangladesh: Historic epidemic patterns suggest earlier mosquito control intervention in the transmission season could reduce the monthly growth factor and extent of epidemics

Abstract

Dengue is endemic in Bangladesh and is an important cause of morbidity and mortality. Suppressing the mosquito vector activity at the optimal time annually is a practical strategy to control dengue outbreaks. The objective of this study was to estimate the monthly growth factor (GF) of dengue cases over the past 12 years as a means to identify the optimal time for a vector-control programme in Bangladesh. We reviewed the monthly cases reported by the Institute of Epidemiology, Disease Control and Research of Bangladesh during the period of January 2008–December 2019. We calculated the GF of dengue cases between successive months during this period and report means and 95% confidence intervals (CI). The median number of patients admitted to the hospital with dengue fever per year was 1554 (range: 375–101,354). The mean monthly GF of dengue cases was 1.2 (95% CI: 0.4–2.4). The monthly GF lower CI between April and July was > 1, whereas from September to November and January the upper CI was <1. The highest GF of dengue was recorded in June (mean: 2.4; 95% CI: 1.7–3.5) and lowest in October (mean: 0.43; 95% CI: 0.24–0.73). More than 81% (39/48) months between April and July for the period 2008–2019 had monthly GF > 1 compared to 20% (19/96) months between August and March of the same period. The monthly GF was significantly correlated with monthly rainfall (r = 0.39) and monthly mean temperature (r = 0.30). The growth factor of the dengue cases over the last 12 years appeared to follow a marked periodicity linked to regional rainfall patterns. The increased transmission rate during the months of April–July, a seasonally determined peak suggests the need for strengthening a range of public health interventions, including targeted vector control efforts and community education campaigns.