Non-random patterns in viral diversity

Anthony, SJ; Islam, A; Johnson, C; Navarrete-Macias, I; Liang, E; Jain, K; Hitchens, PL; Che, X; Soloyvov, A; Hicks, AL; Ojeda-Flores, R; Zambrana-Torrelio, C; Ulrich, W; Rostal, MK; Petrosov, A; Garcia, J; Haider, N; Wolfe, N; Goldstein, T; Morse, SS; Rahman, M; Epstein, JH; Mazet, JK; Daszak, P; Lipkin, WI

doi:10.1038/ncomms9147

Non-random patterns in viral diversity

Anthony, SJ; Islam, A; Johnson, C; Navarrete-Macias, I; Liang, E; Jain, K; Hitchens, PL; Che, X; Soloyvov, A; Hicks, AL; Ojeda-Flores, R; Zambrana-Torrelio, C; Ulrich, W; Rostal, MK; Petrosov, A; Garcia, J; Haider, N; Wolfe, N; Goldstein, T; Morse, SS; Rahman, M; Epstein, JH; Mazet, JK; Daszak, P; Lipkin, WI

Authors

SJ Anthony

A Islam

C Johnson

I Navarrete-Macias

E Liang

K Jain

PL Hitchens

X Che

A Soloyvov

AL Hicks

R Ojeda-Flores

C Zambrana-Torrelio

W Ulrich

MK Rostal

A Petrosov

J Garcia

Najmul Haider n.haider@keele.ac.uk

N Wolfe

T Goldstein

SS Morse

M Rahman

JH Epstein

JK Mazet

P Daszak

WI Lipkin

Abstract

It is currently unclear whether changes in viral communities will ever be predictable. Here we investigate whether viral communities in wildlife are inherently structured (inferring predictability) by looking at whether communities are assembled through deterministic (often predictable) or stochastic (not predictable) processes. We sample macaque faeces across nine sites in Bangladesh and use consensus PCR and sequencing to discover 184 viruses from 14 viral families. We then use network modelling and statistical null-hypothesis testing to show the presence of non-random deterministic patterns at different scales, between sites and within individuals. We show that the effects of determinism are not absolute however, as stochastic patterns are also observed. In showing that determinism is an important process in viral community assembly we conclude that it should be possible to forecast changes to some portion of a viral community, however there will always be some portion for which prediction will be unlikely.

Acceptance Date	Jul 23, 2015
Publication Date	Sep 22, 2015
Journal	Nature Communications
Print ISSN	2041-1723
DOI	https://doi.org/10.1038/ncomms9147
Publisher URL	https://www.nature.com/articles/ncomms9147#article-info

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https://creativecommons.org/licenses/by/4.0/

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Non-random patterns in viral diversity

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