Remote magnetic actuation of cell signalling for tissue engineering

Rotherham, M; Nahar, T; Broomhall, TJ; Telling, N; El Haj, AJ

doi:10.1016/j.cobme.2022.100410

Remote magnetic actuation of cell signalling for tissue engineering

Rotherham, M; Nahar, T; Broomhall, TJ; Telling, N; El Haj, AJ

Authors

M Rotherham

T Nahar

TJ Broomhall

Neil Telling n.d.telling@keele.ac.uk

AJ El Haj

Abstract

Magnetic nanoparticles (MNP) are extremely versatile tools in bioengineering and medicine with diverse uses ranging from magnetic resonance contrast agents to drug delivery vehicles. Recently, MNP have been adapted to target and regulate cell signalling pathways for control of cell behaviour. This approach has been applied to stem and progenitor cells to orchestrate tissue development in tissue engineering. This review introduces the bio-functionalisation mechanisms for MNP and highlights the recent advances in MNP-mediated cell signalling activation. We also explore how the application of this technology has novel uses for stem cell control in the context of tissue engineering and regenerative medicine.

Journal Article Type	Article
Acceptance Date	Aug 10, 2022
Publication Date	Dec 1, 2022
Journal	Current Opinion in Biomedical Engineering
Print ISSN	2468-4511
Publisher	Elsevier
Peer Reviewed	Peer Reviewed
Volume	24
Article Number	100410
DOI	https://doi.org/10.1016/j.cobme.2022.100410
Publisher URL	https://www.sciencedirect.com/science/article/pii/S2468451122000435?via%3Dihub