Watson, L, Belcher, J, Nicholls, E, Chandratre, P, Bucknall, M, Hider, S, Lawton, SA, Mallen, CD, Muller, SN, Rome, K and Roddy, E (2022) Factors associated with change in health-related quality of life in people with gout: a three-year prospective cohort study in primary care. Rheumatology. ISSN 1462-0324

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Objective. To describe factors associated with change in health-related quality of life (HRQOL) in people living with gout in primary care.

Methods. In a UK prospective cohort study, adults with a diagnosis of gout registered with 20 general practices completed the Gout Impact Scale (GIS) (scale 0-100), Short-Form-36 Physical Function subscale (PF10) (0-100) and Health Assessment Questionnaire Disability Index (HAQ-DI) (0-3) via postal questionnaires at baseline and 6, 12, 24 and 36 months. Linear mixed modelling was used to investigate factors associated with change in HRQOL over three years.

Results. 1184 participants responded at baseline (adjusted response 65.6%); 990 (83.6%) were male, mean (SD) age 65.6 (12.5) years. 818, 721, 696, and 605 responded at 6, 12, 24 and 36 months, respectively. Factors associated with worse disease-specific and generic HRQOL over three years were flare frequency (≥5 flares GIS subscales, PF10), oligo/polyarticular flares (GIS subscales, PF10, HAQ-DI), worse pain (GIS subscales, PF10, HAQ-DI), body pain (GIS subscales, PF10, HAQ-DI), and more severe depression (GIS subscales, PF10, HAQ-DI) (p-value ≤ 0.05). More severe anxiety was associated with worse disease-specific HRQOL only (GIS subscales). Older age (PF10), being female (PF10, HAQ-DI) and BMI (HAQ-DI) were associated with worse generic HRQOL (p-value ≤ 0.05).

Conclusion. Gout-specific, comorbid and socio-demographic factors were associated with change in HRQOL over a three-year period highlighting people at risk of worse outcomes who could be targeted for interventions.

Item Type: Article
Additional Information: © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Uncontrolled Keywords: gout; health-related quality of life; primary care; prospective cohort study
Subjects: R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > R735 Medical education. Medical schools. Research
R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine and Health Sciences > School of Medicine
Depositing User: Symplectic
Date Deposited: 22 Dec 2022 11:11
Last Modified: 16 Mar 2023 09:32
URI: https://eprints.keele.ac.uk/id/eprint/11824

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