Bryan Chong
Trends and Predictions of Malnutrition and Obesity in 204 Countries and Territories: an analysis of the Global Burden of Disease Study 2019
Chong, Bryan; Jayabaskaran, Jayanth; Kong, Gwyneth; Huak Chan, Yiong; Han Chin, Yip; Goh, Rachel; Kannan, Shankar; Han Ng, Cheng; Loong, Shaun; Tze Wah Kueh, Martin; Lin, Chaoxing; Vijay Anand, Vickram; Cheng Zhe Lee, Ethan; Jocelyn Chew, H.S.; Jun Hao Tan, Darren; En Chan, Kai; Wang, Jiong-Wei; Muthiah, Mark; Dimitriadis, Georgios K.; Hausenloy, Derek J.; Mehta, Anurag J.; Foo, Roger; Lip, Gregory; Chan, Mark Y.; Mamas, Mamas A.; le Roux, Carel W.; Chew, Nicholas W.S.
Authors
Jayanth Jayabaskaran
Gwyneth Kong
Yiong Huak Chan
Yip Han Chin
Rachel Goh
Shankar Kannan
Cheng Han Ng
Shaun Loong
Martin Tze Wah Kueh
Chaoxing Lin
Vickram Vijay Anand
Ethan Cheng Zhe Lee
H.S. Jocelyn Chew
Darren Jun Hao Tan
Kai En Chan
Jiong-Wei Wang
Mark Muthiah
Georgios K. Dimitriadis
Derek J. Hausenloy
Anurag J. Mehta
Roger Foo
Gregory Lip
Mark Y. Chan
Mamas Mamas m.mamas@keele.ac.uk
Carel W. le Roux
Nicholas W.S. Chew
Abstract
Aims
The effect of the COVID-19 pandemic on care and outcomes across non-COVID-19 cardiovascular (CV) diseases is unknown. A systematic review and meta-analysis was performed to quantify the effect and investigate for variation by CV disease, geographic region, country income classification and the time course of the pandemic.
Methods and results
From January 2019 to December 2021, Medline and Embase databases were searched for observational studies comparing a pandemic and pre-pandemic period with relation to CV disease hospitalisations, diagnostic and interventional procedures, outpatient consultations, and mortality. Observational data were synthesised by incidence rate ratios (IRR) and risk ratios (RR) for binary outcomes and weighted mean differences for continuous outcomes with 95% confidence intervals. The study was registered with PROSPERO (CRD42021265930). A total of 158 studies, covering 49 countries and 6 continents, were used for quantitative synthesis. Most studies (80%) reported information for high-income countries (HICs). Across all CV disease and geographies there were fewer hospitalisations, diagnostic and interventional procedures, and outpatient consultations during the pandemic. By meta-regression, in low-middle income countries (LMICs) compared to HICs the decline in ST-segment elevation myocardial infarction (STEMI) hospitalisations (RR 0.79, 95% confidence interval [CI] 0.66–0.94) and revascularisation (RR 0.73, 95% CI 0.62–0.87) was more severe. In LMICs, but not HICs, in-hospital mortality increased for STEMI (RR 1.22, 95% CI 1.10–1.37) and heart failure (RR 1.08, 95% CI 1.04–1.12). The magnitude of decline in hospitalisations for CV diseases did not differ between the first and second wave.
Conclusions
There was substantial global collateral CV damage during the COVID-19 pandemic with disparity in severity by country income classification.
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 17, 2023 |
Online Publication Date | Feb 16, 2023 |
Publication Date | Mar 1, 2023 |
Publicly Available Date | Jul 6, 2023 |
Journal | EClinicalMedicine |
Print ISSN | 2589-5370 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 57 |
Article Number | 101850 |
Pages | 3164-3178 |
DOI | https://doi.org/10.1016/j.eclinm.2023.101850 |
Keywords | Global burden; Obesity; Malnutrition; Mortality; Disability-adjusted life years |
Publisher URL | https://academic.oup.com/eurheartj/article/43/33/3164/6594507 |
Files
PIIS2589537023000275 (1).pdf
(3 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
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