Dunn, LEM, Ivens, A, Netherton, CL, Chapman, DAG and Beard, PM (2020) Identification of a Functional Small Noncoding RNA of African Swine Fever Virus. Journal of Virology, 94 (21). ISSN 0022-538X

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<jats:p>African swine fever (ASF) poses a major threat to pig populations and food security worldwide. The disease is endemic to Africa and Eastern Europe and is rapidly emerging into Asia, where it has led to the deaths of millions of pigs in the last 12 months. The development of safe and effective vaccines to protect pigs against ASF has been hindered by lack of understanding of the complex interactions between ASFV and the host cell. We focused our work on characterizing the interactions between ASFV and sncRNAs. Although comparatively modest changes to host sncRNA abundances were observed upon ASFV infection, we discovered and characterized a novel functional ASFV-encoded sncRNA. The results from this study add important insights into ASFV host-pathogen interactions. This knowledge may be exploited to develop more effective ASFV vaccines that take advantage of the sncRNA system.</jats:p>

Item Type: Article
Additional Information: Copyright © 2020 Dunn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Subjects: Q Science > QD Chemistry
Q Science > QD Chemistry > QD415 Biochemistry
R Medicine > R Medicine (General) > R735 Medical education. Medical schools. Research
Divisions: Faculty of Natural Sciences > School of Life Sciences
Depositing User: Symplectic
Date Deposited: 06 Feb 2023 13:31
Last Modified: 06 Feb 2023 13:31
URI: https://eprints.keele.ac.uk/id/eprint/11890

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