Haider, N, Hasan, MN, Guitian, J, Khan, RA, McCoy, D, Ntoumi, F, Dar, O, Ansumana, R, Uddin, MJ, Zumla, A and Kock, RA (2023) The disproportionate case-fatality ratio of COVID-19 between top vaccinated countries and the rest of the world. IJID Regions. ISSN 2772-7076

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Objectives We compared the global reported cumulative case-fatality ratio (rCFR) and excess mortality between top-20 countries with COVID-19 vaccination rates, the rest of the world and Sub-Saharan Africa (SSA) before and after commencement of vaccination programmes. Methods We performed time series model to understand the trend of rCFR over time and performed generalized linear mixed model to understand role of vaccination on rCFR. Results By 31 December 2022, on average 260.3 doses of COVID-19 vaccines per 100 people had been administered in the top-20 vaccinated countries, compared to 152.1 doses in the rest of the world, and 51.2 in SSA. The mean rCFR of COVID-19 had dropped by 69.0% in the top in the top-20 vaccinated countries, 26.5% in the rest of the world and 7.6% in SSA. The excess mortality had dropped by 48.7% in top vaccinated countries compared to 62.5% in the rest of the world and 60.7% in SSA. In a generalized linear mixed model, reported number of vaccine doses administered doses (/100 population) (Odds ratio:0.64) was associated with a steeper reduction of the country's COVID-19 rCFR. Conclusions Vaccine equity and faster roll-out across the world is critically important in reducing COVID-19 transmission and CFR.

Item Type: Article
Additional Information: © 2023 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Depositing User: Symplectic
Date Deposited: 10 Feb 2023 11:53
Last Modified: 10 Feb 2023 11:53
URI: https://eprints.keele.ac.uk/id/eprint/11919

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