Peat, G, Kiadaliri, A and Yu, D (2023) Disparities in the age at osteoarthritis diagnosis: an indicator for equity-focussed prevention. Rheumatology. ISSN 1462-0324

[thumbnail of kead080.pdf] Text
kead080.pdf - Accepted Version
Restricted to Repository staff only until 20 February 2024.
Available under License Creative Commons Attribution Non-commercial.

Download (204kB)


Objectives: To investigate the association between vaccination against COVID-19 and inflammatory bowel disease (IBD) flare.
Methods: Patients with IBD vaccinated against COVID-19 who consulted for disease flare between 01/12/2020 and 31/12/2021 were ascertained from the Clinical Practice Research Datalink (CPRD). IBD flares were identified using consultation and corticosteroid prescription records. Vaccinations were identified using product codes and vaccination dates. The study period was partitioned into vaccine-exposed (vaccination date and 21-days immediately after), pre-vaccination (7-days immediately before vaccination), and the remaining vaccine-unexposed periods. Participants contributed data with multiple vaccinations and IBD flares. Season adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CI) were calculated using self-controlled case-series analysis.
Results: Data for 1911 IBD cases, 52% female, mean age 49 years, and 63% with ulcerative colitis (UC) were included. COVID-19 vaccination was not associated with increased IBD flares in the vaccine-exposed period when all vaccinations were considered (aIRR (95%CI) 0.89 (0.77-1.02), 0.79 (0.66-0.95), and 1.00 (0.79–1.27) in IBD overall, UC, and Crohn’s disease respectively). Analyses stratified to include only first, second or third COVID-19 vaccinations found no significant association between vaccination and IBD flares in the vaccine exposed period (aIRR (95%CI) 0.87 (0.71-1.06), 0.93 (0.75-1.15) and 0.86 (0.63-1.17) respectively). Similarly, stratification by COVID-19 before vaccination, and by vaccination with vectored DNA or mRNA vaccine did not reveal an increased risk of flare in any of these subgroups.
Conclusion: Vaccination against COVID-19 was not associated with IBD flares regardless of prior COVID-19 infection and whether mRNA or DNA vaccines were used.

Item Type: Article
Additional Information: The final version of this article and all relevant information related to it, including copyrights, can be found on the publisher website.
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC925 Diseases of the musculoskeletal system
Related URLs:
Depositing User: Symplectic
Date Deposited: 08 Mar 2023 15:16
Last Modified: 08 Mar 2023 15:16

Actions (login required)

View Item
View Item