Keele Research Repository
Explore the Repository
Cross, E, Saunders, B, Farmer, AD and Prior, JA (2023) Diagnostic delay in adult inflammatory bowel disease: A systematic review. Indian Journal of Gastroenterology. ISSN 0254-8860
s12664-022-01303-x.pdf - Published Version
Download (774kB) | Preview
Abstract
BACKGROUND: The extent of diagnostic delay in inflammatory bowel disease (IBD) is incompletely understood. We aimed to understand the extent of diagnostic delay of IBD in adults and identify associations between patient or healthcare characteristics and length of delay. METHODS: Articles were sourced from EMBASE, Medline and CINAHL from inception to April 2021. Inclusion criteria were adult cohorts (18 ≥ years old) reporting median time periods between onset of symptoms for Crohn's disease (CD), ulcerative colitis (UC) or IBD (i.e. CD and UC together) and a final diagnosis (diagnostic delay). Narrative synthesis was used to examine the extent of diagnostic delay and characteristics associated with delay. Sensitivity analysis was applied by the removal of outliers. RESULTS: Thirty-one articles reporting median diagnostic delay for IBD, CD or UC were included. After sensitivity analysis, the majority of IBD studies (7 of 8) reported a median delay of between 2 and 5.3 months. From the studies examining median delay in UC, three-quarters (12 of 16) reported a delay between 2 and 6 months. In contrast, three-quarters of the CD studies (17 of 23) reported a delay of between 2 and 12 months. No characteristic had been examined enough to understand their role in diagnostic delay in these populations. CONCLUSIONS: This systematic review provides robust insight into the extent of diagnostic delay in IBD and suggests further intervention is needed to reduce delay in CD particularly. Furthermore, our findings provide a benchmark value range for diagnostic delay, which such future work can be measured against.
Item Type: | Article |
---|---|
Additional Information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
Uncontrolled Keywords: | Crohn's disease; Diagnostic delay; Inflammatory bowel disease; Ulcerative colitis |
Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine |
Divisions: | Faculty of Medicine and Health Sciences > School of Medicine |
Related URLs: | |
Depositing User: | Symplectic |
Date Deposited: | 17 Mar 2023 14:48 |
Last Modified: | 20 Mar 2023 13:40 |
URI: | https://eprints.keele.ac.uk/id/eprint/12049 |