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Miller, GJ, Hansen, SU, Avizienyte, E, Rushton, G, Cole, C, Jayson, GC and Gardiner, JM (2013) Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2-and VEGF(165)-mediated endothelial cell functions. Chemical Science, 4 (8). 3218 - 3222. ISSN 2041-6520
G Miller - Efficient chemical synthesis of heparin-like octa- deca- and dodecasaccharides and inhibition....pdf - Accepted Version
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Abstract
A concise chemical synthesis of a series of structurally-defined heparin-like oligosaccharides is described. This work provides an efficient entry to octa-, deca-, and dodecasaccharides, including the first synthesis of (GlcNS6S-IdoA2S)5 and (GlcNS6S-IdoA2S)6. Evaluation of the in vitro activity of these species against FGF2- and VEGF165-dependent endothelial cell proliferation and migration establishes that octa- and decasaccharides are more potent in targeting FGF2-induced effects, where cell migration is affected more significantly than proliferation. These structure–activity relationships exemplify the significance of 6-O-sulfation in regulating the activity of angiogenic growth factors.
Item Type: | Article |
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Subjects: | Q Science > QD Chemistry |
Divisions: | Faculty of Natural Sciences > School of Physical and Geographical Sciences |
Related URLs: | |
Depositing User: | Symplectic |
Date Deposited: | 30 Nov 2015 15:20 |
Last Modified: | 30 May 2019 12:45 |
URI: | https://eprints.keele.ac.uk/id/eprint/1220 |