Hansen, SU, Miller, GJ, Jayson, GC and Gardiner, JM (2013) First Gram-Scale Synthesis of a Heparin-Related Dodecasaccharide. Organic Letters, 15 (1). 88 - 91. ISSN 1523-7060

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The first example of a gram-scale synthesis of a structurally defined, heparin-related dodecasaccharide is reported. An iterative 14-step process using an iduronate donor disaccharide delivers >1g quantities of the dodecasaccharide sequence [GlcNS-IdoA2S]6-OMe in 15% overall yield from the reducing terminal disaccharide, a 2 orders of magnitude increase in scale for access to synthetic heparanoid dodecasaccharide mimetics. The synthesis also delivers multigram amounts of the protected oligosaccharides from tetra- through to dodecasaccharide.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural Sciences > School of Physical and Geographical Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 26 Nov 2015 11:26
Last Modified: 24 May 2019 14:28
URI: https://eprints.keele.ac.uk/id/eprint/1221

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