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The UK Biobank imaging enhancement of 100,000 participants:?rationale, data collection, management and future directions

Neubauer, S; Littlejohns, TJ; Holliday, J; Gibson, LM; Garratt, S; Oesingmann, N; Alfaro-Almagro, F; Bell, JD; Boultwood, C; Collins, R; Conroy, MC; Crabtree, N; Doherty, N; Frangi, AF; Harvey, NC; Leeson, P; Miller, KL; Petersen, SE; Sellors, J; Sheard, S; Smith, SM; Sudlow, CLM; Matthews, PM; Allen, NE; Kariki, E

The UK Biobank imaging enhancement of 100,000 participants:?rationale, data collection, management and future directions Thumbnail


Authors

S Neubauer

TJ Littlejohns

J Holliday

LM Gibson

S Garratt

N Oesingmann

F Alfaro-Almagro

JD Bell

C Boultwood

R Collins

MC Conroy

N Crabtree

N Doherty

AF Frangi

NC Harvey

P Leeson

KL Miller

SE Petersen

J Sellors

S Sheard

SM Smith

CLM Sudlow

PM Matthews

NE Allen

E Kariki



Abstract

<jats:title>Abstract</jats:title><jats:p>UK Biobank is a population-based cohort of half a million participants aged 40–69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world’s largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions.</jats:p>

Acceptance Date Apr 3, 2020
Publication Date May 26, 2020
Publicly Available Date Mar 29, 2024
Journal Nature Communications
Print ISSN 2041-1723
DOI https://doi.org/10.1038/s41467-020-15948-9
Publisher URL https://www.nature.com/articles/s41467-020-15948-9

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