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Jayson, GC, Hansen, SU, Miller, GJ, Cole, CL, Rushton, G, Avizienyte, E and Gardiner, JM (2015) Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology. Chemical Communications, 51 (72). 13846 -13849. ISSN 1364-548X

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Abstract

he multigram-scale synthesis of a sulfation-site programmed heparin-like dodecasaccharide is described. Evaluation alongside dodecasaccharides lacking this single glucosamine O6-sulfation, or having per-O6-sulfation, shows that site-specific modification of the terminal glucosamine dramatically interconverts regulation of in vitro and in vivo biology mediated by the two important chemokines, CXCL12 (SDF1α) or CXCL8 (IL-8).

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 26 Nov 2015 09:55
Last Modified: 03 Mar 2020 13:49
URI: https://eprints.keele.ac.uk/id/eprint/1229

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