Miller, GJ, Broberg, KR, Rudd, C, Helliwell, MR, Jayson, GC and Gardiner, JM (2015) A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides. Organic & Biomolecular Chemistry, 2015 (13). pp. 11208-11219. ISSN 1477-0539

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D-Glucosamine derivatives bearing latent O4 functionality provide modified H/HS-type disaccharide donors for a final stage capping approach enabling introduction of conjugation-suitable, non-reducing terminal functionality to biologically important glycosaminoglycan oligosaccharides. Application to the synthesis of the first O4-terminus modified synthetic LMWH decasaccharide and an HS-like dodecasaccharide is reported.

Item Type: Article
Subjects: Q Science > QD Chemistry
R Medicine > R Medicine (General)
Divisions: Faculty of Natural Sciences > School of Physical and Geographical Sciences
Depositing User: Symplectic
Date Deposited: 26 Nov 2015 09:27
Last Modified: 24 Apr 2019 08:48

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