Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?

Hinton, Jonathan; Augustine, Maclyn; Gabara, Lavinia; Mariathas, Mark; Allan, Rick; Borca, Florina; Nicholas, Zoe; Gillett, Neil; Kwok, Chun Shing; Cook, Paul; Grocott, Michael PW; Mamas, Mamas; Curzen, Nick

doi:10.1177/17511437231160078

Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?

Hinton, Jonathan; Augustine, Maclyn; Gabara, Lavinia; Mariathas, Mark; Allan, Rick; Borca, Florina; Nicholas, Zoe; Gillett, Neil; Kwok, Chun Shing; Cook, Paul; Grocott, Michael PW; Mamas, Mamas; Curzen, Nick

Authors

Jonathan Hinton

Maclyn Augustine

Lavinia Gabara

Mark Mariathas

Rick Allan

Florina Borca

Zoe Nicholas

Neil Gillett

Chun Shing Kwok

Paul Cook

Michael PW Grocott

Mamas Mamas m.mamas@keele.ac.uk

Nick Curzen

Abstract

The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general CC unit (GCCU) and neuroscience CC unit (NCCU) who had hs-cTnI tests performed throughout their CC admission, regardless of whether the test was clinically indicated. Cox proportional hazards were used to estimate the risk of 1-year mortality. A landmark analysis was undertaken to assess whether any relationship at 1 year was driven by mortality within the first 30 days. A total of 1033 consecutive patients were included. At 1 year 254 (24.6%) patients had died. The admission log(10)hs-cTnI concentration in the entire cohort (HR 1.35 (95% CI 1.05–1.75) p = 0.009 with a bootstrap of 1000 samples) was independently associated with 1 year mortality. On landmark analysis the association with 1 year mortality was driven by 30 day mortality. These results indicate that admission hs-cTnI concentration is independently associated with 1 year mortality in CC and this relationship may be driven by differences in mortality at 30 days.

Journal Article Type	Article
Acceptance Date	Apr 30, 2023
Online Publication Date	Mar 30, 2023
Publication Date	Mar 30, 2023
Journal	Journal of the Intensive Care Society
Print ISSN	1751-1437
Publisher	SAGE Publications
Peer Reviewed	Peer Reviewed
Volume	24
Issue	4
Pages	392-398
DOI	https://doi.org/10.1177/17511437231160078
Keywords	High sensitivity troponin; myocardial infarction; critical care
Publisher URL	https://journals.sagepub.com/doi/10.1177/17511437231160078

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Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?

Hinton, Jonathan; Augustine, Maclyn; Gabara, Lavinia; Mariathas, Mark; Allan, Rick; Borca, Florina; Nicholas, Zoe; Gillett, Neil; Kwok, Chun Shing; Cook, Paul; Grocott, Michael PW; Mamas, Mamas; Curzen, Nick

Authors

Abstract

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