Jonathan Hinton
Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?
Hinton, Jonathan; Augustine, Maclyn; Gabara, Lavinia; Mariathas, Mark; Allan, Rick; Borca, Florina; Nicholas, Zoe; Gillett, Neil; Kwok, Chun Shing; Cook, Paul; Grocott, Michael PW; Mamas, Mamas; Curzen, Nick
Authors
Maclyn Augustine
Lavinia Gabara
Mark Mariathas
Rick Allan
Florina Borca
Zoe Nicholas
Neil Gillett
Chun Shing Kwok
Paul Cook
Michael PW Grocott
Mamas Mamas m.mamas@keele.ac.uk
Nick Curzen
Abstract
The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general CC unit (GCCU) and neuroscience CC unit (NCCU) who had hs-cTnI tests performed throughout their CC admission, regardless of whether the test was clinically indicated. Cox proportional hazards were used to estimate the risk of 1-year mortality. A landmark analysis was undertaken to assess whether any relationship at 1 year was driven by mortality within the first 30 days. A total of 1033 consecutive patients were included. At 1 year 254 (24.6%) patients had died. The admission log(10)hs-cTnI concentration in the entire cohort (HR 1.35 (95% CI 1.05–1.75) p = 0.009 with a bootstrap of 1000 samples) was independently associated with 1 year mortality. On landmark analysis the association with 1 year mortality was driven by 30 day mortality. These results indicate that admission hs-cTnI concentration is independently associated with 1 year mortality in CC and this relationship may be driven by differences in mortality at 30 days.
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 30, 2023 |
Online Publication Date | Mar 30, 2023 |
Publication Date | Mar 30, 2023 |
Journal | Journal of the Intensive Care Society |
Print ISSN | 1751-1437 |
Publisher | SAGE Publications |
Peer Reviewed | Peer Reviewed |
Volume | 24 |
Issue | 4 |
Pages | 392-398 |
DOI | https://doi.org/10.1177/17511437231160078 |
Keywords | High sensitivity troponin; myocardial infarction; critical care |
Publisher URL | https://journals.sagepub.com/doi/10.1177/17511437231160078 |
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