Hinton, J, Augustine, M, Gabara, L, Mariathas, M, Allan, R, Borca, F, Nicholas, Z, Gillett, N, Kwok, CS, Cook, P, Grocott, MPW, Mamas, MA and Curzen, N (2023) Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients? Journal of the Intensive Care Society. ISSN 1751-1437

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The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general CC unit (GCCU) and neuroscience CC unit (NCCU) who had hs-cTnI tests performed throughout their CC admission, regardless of whether the test was clinically indicated. Cox proportional hazards were used to estimate the risk of 1-year mortality. A landmark analysis was undertaken to assess whether any relationship at 1 year was driven by mortality within the first 30 days. A total of 1033 consecutive patients were included. At 1 year 254 (24.6%) patients had died. The admission log(10)hs-cTnI concentration in the entire cohort (HR 1.35 (95% CI 1.05–1.75) p = 0.009 with a bootstrap of 1000 samples) was independently associated with 1 year mortality. On landmark analysis the association with 1 year mortality was driven by 30 day mortality. These results indicate that admission hs-cTnI concentration is independently associated with 1 year mortality in CC and this relationship may be driven by differences in mortality at 30 days.

Item Type: Article
Additional Information: The final version of this article and all relevant information related to it, including copyrights, can be found on the publisher website.
Subjects: R Medicine > R Medicine (General)
Depositing User: Symplectic
Date Deposited: 04 May 2023 08:27
Last Modified: 04 May 2023 08:27
URI: https://eprints.keele.ac.uk/id/eprint/12356

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