Aboukhater, D, Morad, B, Nasrallah, N, Nasser, SA, Sahebkar, A, Kobeissy, F, Boudaka, A and Eid, AH (2023) Inflammation and hypertension: Underlying mechanisms and emerging understandings. Journal of Cellular Physiology. ISSN 1097-4652

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Hypertension remains a major contributor to cardiovascular disease (CVD), a leading cause of global death. One of the major insults that drive increased blood pressure is inflammation. While it is the body's defensive response against some homeostatic imbalances, inflammation, when dysregulated, can be very deleterious. In this review, we highlight and discuss the causative relationship between inflammation and hypertension. We critically discuss how the interplay between inflammation and reactive oxygen species evokes endothelial damage and dysfunction, ultimately leading to narrowing and stiffness of blood vessels. This, along with phenotypic switching of the vascular smooth muscle cells and the abnormal increase in extracellular matrix deposition further exacerbates arterial stiffness and noncompliance. We also discuss how hyperhomocysteinemia and microRNA act as links between inflammation and hypertension. The premises we discuss suggest that the blue-sky scenarios for targeting the underlying mechanisms of hypertension necessitate further research.

Item Type: Article
Additional Information: The published version of this article can be accessed directly from the publishers website
Uncontrolled Keywords: cardiovascular disease; cytokines; endothelium; microRNA; vascular smooth muscle
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > School of Medicine
Related URLs:
Depositing User: Symplectic
Date Deposited: 12 May 2023 07:32
Last Modified: 12 May 2023 07:32
URI: https://eprints.keele.ac.uk/id/eprint/12616

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