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Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis

Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis Thumbnail


Abstract

The pathology of ankylosing spondylitis (AS) suggests that certain cytokines and matrix metalloproteinases (MMPs) might provide useful markers of disease activity. Serum levels of some cytokines and MMPs have been found to be elevated in active disease, but there is a general lack of information about biomarker profiles in AS and how these are related to disease activity and function. The purpose of this study was to investigate whether clinical measures of disease activity and function in AS are associated with particular profiles of circulating cytokines and MMPs.

Acceptance Date May 28, 2012
Publication Date Jan 1, 2012
Publicly Available Date Mar 29, 2024
Journal Arthritis Research & Therapy
Print ISSN 1478-6354
Publisher Springer Verlag
Pages R127 - ?
DOI https://doi.org/10.1186/ar3857
Keywords ankylosing spondylitis, matrix metalloproteinase

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