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Chen, Y, Dawes, PT, Packham, JC and Mattey, DL (2012) Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study. Arthritis Research & Therapy, 14 (2). R81 -?. ISSN 1478-6354
Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study..pdf - Published Version
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Abstract
Transforming growth factor-beta1 (TGF-beta1) is a pleiotropic cytokine that plays important roles in immunity and inflammation. Some studies have suggested that polymorphism in the TGFB1 gene is associated with heart disease in the general population. The purpose of the present study was to determine whether common single-nucleotide polymorphisms (SNP) in the TGFB1 gene are associated with ischaemic heart disease (IHD) and/or myocardial infarction (MI) in patients with rheumatoid arthritis (RA), and to investigate the influence of smoking on any association.
| Item Type: | Article |
|---|---|
| Additional Information: | This is the final published version of the article (version of record). It first appeared online via BioMed Central at https://dx.doi.org/10.1186/ar3804 - please refer to any applicable terms of use of the publisher. |
| Uncontrolled Keywords: | smoking, heart failure, rheumatoid arthritis |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine |
| Related URLs: | |
| Depositing User: | Symplectic |
| Date Deposited: | 27 Nov 2014 09:48 |
| Last Modified: | 17 Dec 2018 16:30 |
| URI: | https://eprints.keele.ac.uk/id/eprint/129 |
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