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Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study

Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study Thumbnail


Abstract

Transforming growth factor-beta1 (TGF-beta1) is a pleiotropic cytokine that plays important roles in immunity and inflammation. Some studies have suggested that polymorphism in the TGFB1 gene is associated with heart disease in the general population. The purpose of the present study was to determine whether common single-nucleotide polymorphisms (SNP) in the TGFB1 gene are associated with ischaemic heart disease (IHD) and/or myocardial infarction (MI) in patients with rheumatoid arthritis (RA), and to investigate the influence of smoking on any association.

Acceptance Date Apr 18, 2012
Publication Date Apr 18, 2012
Journal Arthritis Research & Therapy
Print ISSN 1478-6354
Publisher Springer Verlag
Pages R81 -?
DOI https://doi.org/10.1186/ar3804
Keywords smoking, heart failure, rheumatoid arthritis
Publisher URL http://dx.doi.org/10.1186/ar3804

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